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KMID : 1149220030110020159
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Korean Journal of Oriental Medical Prescription
2003 Volume.11 No. 2 p.159 ~ p.171
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The effects of Salviae Miltiorrhizae Radix(SR), Carthami Flos(CF) and Acori Graminei Rhizoma(AR) to cerebral contusion
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Kim Haeng-Jin
Jeon Sang-Yoon
Kim Jeong-Sang
Kim Kyung-Soo
Hong Seok
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Abstract
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This study was done to investigate effects of SR, CF and AR to angiogenesis of cerebral tissues, protecting damage of cerebral neurons and activating them in cerebral contusion-induced rats. I observed these conclusions as follows ; 1. Observation of VEGF-immunoreactive cells : Groups of administered AR were not meaningful in increasing VEGF-immunoreactive cells for 3 days and 7 days, groups of administered SR meaningfully increased them to control groups in all groups, and groups of administered CF meaningfully increased them to control groups in all groups, too, interestingly, increased double to control group for 7 days. 2. Observation on cerebral neurons by Cresyl violet stain : Dendrites and axons of groups of administered SR, AR for 3 days were clearly observed to control group. Cerebral neurons of groups of administered CF for 3days and 7 days were increased a little, but were not meaningful. In conclusion, AR will be careful of being used in cerebral contusion. CF and SR were effective to activating cerebral hemokinesis by inducing angiogenesis in trauma of tissue, but weakly to protecting trauma of cerebral neurons and activating them. I think more studies will be done in these facts.
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KEYWORD
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Cerebral contusion, Salviae Miltiorrhizae Radix(SR), Carthami Flos(CF), Acori Graminei Rhizoma(AR)
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